Endocrine Abstracts

54 year old lady presented to the endocrine clinic. She was diagnosed with breast cancer and right ovarian tumour at the same time in August 2015. She had right lumpectomy of breast and Salpingo-Oophorectomy in November 2015. She was not feeling very well for the last few weeks. She complained of extreme lethargy and tiredness. She had blood test done on 15th November 2016 that showed prolactin level at 2849 nmmol/l with negative macroprolactin. Hence, she was referred to the ...

We report a 61-year-old female with a history of bronchiectasis, primary Sjogren’s syndrome and osteoporosis. She had taken oral glucocorticoids initiated by the rheumatologists for 10 years, which were stopped 2 years ago. She was referred to the Endocrine Clinic with a short history of polyuria and polydipsia. Biochemistry confirmed new hypercalcaemia and an acute kidney injury: corrected calcium 3.14 mmol/l, phosphate 1.13 mmol/l and 25-hydroxyvitamin D 66.4 nmol/l. At...

Africo Caribbean gentleman was referred to our endocrine department for management of secondary hypertension. He initially presented to his doctor with headache and he was found to be hypertensive with systolic BP of 200 mmHg and hypokalaemia. A renal MRI showed a right adrenal mass, 2.9×2.4 cm, and echocardiogram showed moderate left ventricular hypertrophy and diastolic dysfunction. He had normal 24 h excretion of metanephrines and free cortisol. An aldosterone renin ra...

Background: Hyponatraemia is the most common electrolyte abnormality in hospitalised patients. It is an independent risk factor for mortality and is associated with increased length of hospital stay.Method: The objective of audit was to review practice of investigations and management of hyponatraemia in adults at Bedford hospital in line with evidence based guidelines including European Society of Endocrinology 2014 clinical practice guidance. An observ...

Introduction: BTA guidelines-2014 outlined the need for key features to be included in thyroid ultrasound scan (USS) reporting including risk stratification. The aim of this audit was to evaluate the quality of thyroid-USS reporting at Northumbria Healthcare NHS Foundation Trust (NHCT); using BTA guidelines as the gold standard.Methods: All thyroid/neck-USS between 1st November to 31st December 2015 were retrieved from radiology records at NHCT. Scans ev...

Inappropriately low circulating PTH levels following thyroid surgery, is the most common cause of iatrogenic hypocalcaemia. Standard treatment of hypoparathyroidism has comprised vitamin D analogue and calcium supplementation. However some patients remain hypocalcaemic despite use of maximal titrated and tolerated therapy. Teriparatide is recombinant formulation of endogenous PTH, containing 34 amino acid sequence which is identical to the N-terminal portion of this hormone. W...

Over the last few years, there has been an increase in the demand on the National Health Service, with patients presenting to hospital with multiple co-morbidities and increasingly complex needs. The type of endocrine referrals received can vary both in complexity and also between clinicians. The Royal College of physician has published a ‘Referring wisely’ report in June 2017 which aims to improve and streamline the quality of referrals received in each speciality. ...

Background: Healthcare organisations worldwide are making use of patient-reported outcome measures (PROMs) to assess the impact of care received on patient’s health-related quality of life.Aim: A cross-sectional pilot study designed to evaluate the suitability and validity of a proposed pituitary PROM questionnaire pack for patients having pituitary surgery.Methods: The PROM pack comprised five questionnaires focused on sympto...

Introduction: Pancreatogenic diabetes (Type 3c diabetes-T3cDM) is rare in children, and frequently underdiagnosed. The prevalence is 5–10% of all adult diabetes cases in the developed world. Over 78% of people with T3cDM have chronic pancreatitis.Case: A 15-year old presented with polyuria, polydipsia, abdominal pain, weight loss (WL) and a three-generational family history of type-1 (T1DM) and type-2 diabetes mellitus (T2DM). Examination revealed m...

Introduction: Primary hyperparathyroidism (P-HPT) is a common endocrine disorder that occurs as result of adenomas (80–85%), hyperplasia (10–15%), atypical adenoma or carcinomas (<1%). Atypical parathyroid adenoma (APA) is a rare entity and represents intermediate group of parathyroid neoplasms of uncertain malignant potential with some atypical histological features.Case details: We report a case of a 34-year male, with a background of h...